In a groundbreaking development, Shimadzu Corporation has unveiled the world’s first quadrupole time-of-flight (TOF) mass spectrometer integrated with oxygen attachment dissociation (OAD) technology. This innovative system promises to transform the detailed structural analysis of lipids and other complex natural compounds.
Understanding the OAD-TOF System
The OAD-TOF system is a quantum leap in mass spectrometry, combining the precision of quadrupole TOF mass spectrometry with the advanced capabilities of OAD. The system’s ability to estimate the position of double bonds between carbon atoms in organic compounds is a significant advancement, particularly for compounds where this was previously a challenging task.
Comparison of Traditional TOF and OAD-TOF Systems
| Feature | Traditional TOF | OAD-TOF System |
|---|---|---|
| Double Bond Localization | Difficult | Precise with OAD |
| Sample Analysis | General | Detailed structural analysis |
| Application Fields | Broad | Lipids, natural compounds |
| Technology | Standard MS | Quadrupole TOF with OAD |
The Impact of OAD Technology
Developed at the Koichi Tanaka Mass Spectrometry Research Laboratory, OAD technology introduces atomic oxygen to react with ionized samples. This process selectively breaks the double bonds between carbon atoms, generating ion fragments that reveal the position of these bonds. The quadrupole TOF mass spectrometer then measures the size and quantity of these fragments, providing precise compound information.
Applications and Future Prospects
The OAD-TOF system’s detailed structural analysis capability is crucial for research and development in pharmaceuticals and food products. By elucidating structures that include bond positions between carbon atoms, the system aids in understanding compound characteristics and functions, such as the health benefits of omega-3 fatty acids.
Shimadzu’s commitment to innovation continues to support advancements in healthcare and life sciences. The OAD-TOF system is not just a tool for today’s researchers but a foundation for tomorrow’s discoveries.
